A serious collision that shut down the Queen Elizabeth II Highway south of Edmonton late Monday morning has left three people dead, RCMP confirmed to CTV News.

Leduc RCMP said the single-vehicle collision was first reported at about 10:40 a.m. just south of construction for the new 41 Avenue overpass.

Investigators said the vehicle had come in contact with the shoulder of the highway before losing control – the vehicle rolled several times in the middle of the southbound lanes.

Police later confirmed three people were found deceased as a result of the crash, and one person was airlifted by STARS to hospital in Edmonton. RCMP said the female’s condition was believed to be very grave.

Witnesses told CTV News the vehicle involved in the crash crossed three lanes of traffic before the collision.

That section of highway was shut down for several hours Monday – Edmonton police said it was reopened after 3 p.m.

Police said the Medical Examiner’s office had been engaged to determine the exact cause of death of the three individuals killed in the crash.

The extensive closure also caused some problems for Edmontonians heading to the Edmonton International Airport.

WestJet officials told CTV News that any passengers who missed their flights were rebooked at a later flight at no extra charge. Air Canada also said accommodations were made to help passengers affected by the crash.

With files from Brenna Rose